Can erythrocytes release biologically active NO?
Peter M. Benz
Ingrid Fleming
To start this off we first must know what a erythrocytes is and that is the red blood cell itself that transfers oxygen and carbon dioxide to form tissues in the human body. NO is endothelial nitric oxide and is essentially neural activity. Nitric Oxide (NO) is claimed to be the dependent variable in regulation of cell function along with erythrocytes. There is a hypothesis that claims that erythrocytes also play a role in platelet inhibition by generating or release of NO or NO-carriers. The Erythrocytes will activate in the platelets will extend the bleeding rate in mammals who are anemia independent in platelet count. Which means that the bleeding defects could possibly have a connection with an impaired platelet activation. It is unsure how Erythrocytes contribute to platelet activation but we can infer that it might be due to the activation of ADP-P2Y, a receptor pathway that moves the elevated platelet radials and interaction with the endothelium. 3 different people have came up with possible reasons why there might be no active NO released by erythrocytes; However, there is still a doubt to all these hypothesis, which is “NO from erythrocytes come from the fact that Hb is an avid scavenger of NO”.
This study relates to class because the erythrocytes are signal molecules that functions within the cell cycle. We can connect the transfer of oxygen and carbon dioxide within the cell to cell communication.
This research is cutting edge because scientists are trying to find out if erythrocytes will release nitric oxide in platelet activation
In this article I learned that nitric oxide is generated in endothelial cells, which is whole process in its own that I have never learned before
I picked this article because in class we have been talking about cell communication and I thought that I could maybe learn something through this article since it correlates with cell communication and sure enough I did
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